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  Indian J Med Microbiol
 

Figure 5: Histopathological results of the liver in mice. (A1-A2) The finasteride group shows parenchymal inflammation (*), hepatocellular necrosis (#), and sinusoidal obstruction ($). Endothelial injuries in small hepatic venules (&) lead to endothelial swelling, thrombosis, and luminal occlusion (^). (A2 & C) Sinusoidal dilatation and congestion, as well as the destruction of hepatocytes’ nuclei and some necrotic hepatocytes with the basophilic (1) and residual eosinophilic (2) bodies filled with granules are seen. (B, C and D) The treatment groups (100, 200 and 400 mg/kg/day of Origanum vulgare extract) show improved structure of the liver, which is more pronounced at the dose of 400 mg/kg. Hepatocytes have a normal structure (without eosinophilic granules). No congestion and obstruction of the central venule or lymphocyte infiltration is observed. (E) The normal group shows the normal structure of the hepatocytes, central venules, and liver arteries. n: normal hepatocytes; 1: basophilic hepatocytes; 2: eosinophilic hepatocytes; CV: central venule and NL: normal lobule [A1, A2, B, C, D, and E, H&E X100 (scale bar = 100 μm)].

Figure 5: Histopathological results of the liver in mice. (A1-A2) The finasteride group shows parenchymal inflammation (*), hepatocellular necrosis (#), and sinusoidal obstruction ($). Endothelial injuries in small hepatic venules (&) lead to endothelial swelling, thrombosis, and luminal occlusion (<sup>^</sup>). (A2 & C) Sinusoidal dilatation and congestion, as well as the destruction of hepatocytes’ nuclei and some necrotic hepatocytes with the basophilic (1) and residual eosinophilic (2) bodies filled with granules are seen. (B, C and D) The treatment groups (100, 200 and 400 mg/kg/day of <i>Origanum vulgare</i> extract) show improved structure of the liver, which is more pronounced at the dose of 400 mg/kg. Hepatocytes have a normal structure (without eosinophilic granules). No congestion and obstruction of the central venule or lymphocyte infiltration is observed. (E) The normal group shows the normal structure of the hepatocytes, central venules, and liver arteries. n: normal hepatocytes; 1: basophilic hepatocytes; 2: eosinophilic hepatocytes; CV: central venule and NL: normal lobule [A1, A2, B, C, D, and E, H&E X100 (scale bar = 100 μm)].