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Year : 2021  |  Volume : 11  |  Issue : 8  |  Page : 327-334

Anti-viral and anti-inflammatory effects of kaempferol and quercetin and COVID-2019: A scoping review

1 Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
2 Department of Physiology, Jiroft University of Medical Sciences, Jirof, Iran
3 Center for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Ministry of Scientific Research and Innovations, Yaounde, Cameroon

Correspondence Address:
Mohammad Reza Khazdair
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2221-1691.319567

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Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a novel coronavirus identified at the end of 2019. It is recognized as the causative agent of coronavirus disease 2019 (COVID-19). Flavonoids have been shown to exhibit therapeutical effect on complications related to COVID-19. The present study reviews possible therapeutic benefits of flavonoids on SARS-CoV-2. The Web of Science, PubMed, Scopus, and Google Scholar were searched using keywords: “COVID-19”, “SARS-CoV-2”, “Kaempferol” and “Quercetin” in the Title/Abstract. Relevant published articles in the English language until August 2020 were considered. Kaempferol and quercetin showed antiviral properties such as inhibition of protein kinase B and phosphorylation of protein kinase and blocking effects on a selective channel (3a channel) expressed in SARS-CoV infected cells. They also reduced the level of reactive oxygen species, expression of inducible nitric oxide synthase, pro-inflammatory mediators including TNF-α, IL-1α, IL-1β, IL-6, IL-10, and IL-12 p70, and chemokines. Kaempferol and quercetin might exert beneficial effects in the control or treatment of COVID-19 because of their antiviral, antioxidant, anti-inflammatory, and immunomodulatory effects.

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