| ORIGINAL ARTICLE |
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| Year : 2021 | Volume
: 11
| Issue : 5 | Page : 183-193 |
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Protective effects of rice bran hydrolysates on heart rate variability, cardiac oxidative stress, and cardiac remodeling in high fat and high fructose diet-fed rats
Ketmanee Senaphan1, Upa Kukongviriyapan2, Pisit Suwannachot3, Geerasak Thiratanaboon3, Weerapon Sangartit2, Supawan Thawornchinsombut4, Akkasit Jongjareonrak5
1 Division of Physiology, Faculty of Veterinary Medicine; Cardiovascular Research Group, Khon Kaen University, Khon Kaen 40002, Thailand
2 Cardiovascular Research Group; Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
3 Division of Physiology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
4 Department of Food Technology, Faculty of Technology, Khon Kaen University, Khon Kaen 40002, Thailand
5 Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand
Correspondence Address:
Ketmanee Senaphan
Division of Physiology, Faculty of Veterinary Medicine; Cardiovascular Research Group, Khon Kaen University, Khon Kaen 40002
Thailand
 Source of Support: This work was financially supported by the Young Researcher Development Project of Khon Kaen University, 2018, Conflict of Interest: None
DOI: 10.4103/2221-1691.311754
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Objective: To examine the ameliorative effect of rice bran hydrolysates (RBH) on metabolic disorders, cardiac oxidative stress, heart rate variability (HRV), and cardiac structural changes in high fat and high fructose (HFHF)-fed rats.
Methods: Male Sprague-Dawley rats were daily fed either standard chow diet with tap water or an HFHF diet with 10% fructose in drinking water over 16 weeks. RBH (500 and 1 000 mg/kg/day) was orally administered to the HFHF-diet-fed rats during the last 6 weeks of the study period. At the end of the treatment, metabolic parameters, oxidative stress, HRV, and cardiac structural changes were examined.
Results: RBH administration significantly ameliorated metabolic disorders by improving lipid profiles, insulin sensitivity, and hemodynamic parameters. Moreover, RBH restored HRV, as evidenced by decreasing the ratio of low-frequency to high-frequency power of HRV, a marker of autonomic imbalance. Cardiac oxidative stress was also mitigated after RBH supplementation by decreasing cardiac malondialdehyde and protein carbonyl, upregulating eNOS expression, and increasing catalase activity in the heart. Furthermore, RBH mitigated cardiac structural changes by reducing cardiac hypertrophy and myocardial fibrosis in HFHF-diet-fed rats.
Conclusions: The present findings suggest that consumption of RBH may exert cardioprotective effects against autonomic imbalances, cardiac oxidative stress, and structural changes in metabolic syndrome. |
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