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SHORT COMMUNICATION
Year : 2020  |  Volume : 10  |  Issue : 12  |  Page : 563-568

Teicoplanin is a potential inhibitor of SARS CoV-2 replication enzymes: A docking study


Institute of Chemistry, University of the Punjab, New Campus, Lahore-54590, Pakistan

Correspondence Address:
Muhammad Asim Raza Basra
Institute of Chemistry, University of the Punjab, New Campus, Lahore-54590
Pakistan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2221-1691.294093

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Objective: To explore potential inhibitors of viral enzymes of SARS CoV-2. Methods: The in-silico docked potential of anti-viral, antibiotic, and analgesic drugs were studied for inhibition of the nonstructural protein (NSP) 9, NSP3, and NSP15 of SARS CoV-2 using recent structural peculiarities of these enzymes, 3D optimized structures of drugs and algorithm-based ligand inhibitory potential. Results: Teicoplanin, azithromycin, and remdesivir potentially inhibited NSP9 (Dock-score 9 620, 5 472 and 6 252, respectively), NSP3 (Dock-score 9 846, 5 604 and 5 548, respectively) and NSP15 (Dock-score 10 960, 6414 and 6 002, respectively). Conclusions: Teicoplanin acts as a significant receptor antagonist and potentially inhibits the SARS CoV-2 enzymes.


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