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ORIGINAL ARTICLE
Year : 2020  |  Volume : 10  |  Issue : 11  |  Page : 496-504

Phytochemical profile, antioxidant activity and wound healing properties of Artemisia absinthium essential oil


1 Department of Microbiology and Biochemistry, Faculty of Sciences, University of M'sila, Algeria
2 Istituto del CNR di Chimica Biomolecolare, Catania, Italy
3 Department of Biological Sciences, Faculty of Nature and Life Sciences, University of BBA, Algeria

Correspondence Address:
A Boudjelal
Department of Microbiology and Biochemistry, Faculty of Sciences, University of M'sila
Algeria
G Ruberto
Istituto del CNR di Chimica Biomolecolare, Catania
Italy
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Source of Support: This work was supported by Algerian Ministry of Higher Education and Scientific Research/ Algeria (CNEPRU: DO1N01UN280120150001) and Consiglio Nazionale delle Ricerche, Rome, Italy, Conflict of Interest: None


DOI: 10.4103/2221-1691.294089

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Objective: To evaluate chemical compositions, antioxidant and wound healing properties of Algerian Artemisia absinthium essential oil. Methods: The chemical composition of the essential oil from Artemisia absinthium was analyzed by a combination of GC-FID and GC/MS. The antioxidant capacities including the total antioxidant capacity, DPPH and ABTS+• scavenging capacities were measured. The wound healing potential was assessed by the excision wound model of rats. The wounds were treated daily with an ointment prepared with two concentrations (5% and 10%) of Artemisia absinthium essential oil. The percentage of wound contraction was determined and wound healing was also evaluated by histological examination of the healed skin. Results: The main component of Artemisia absinthium essential oil was camphor (48%) followed by chamazulene (10%) that was responsible for the dark blue color of the oil. Artemisia absinthium essential oil exhibited moderate antioxidant activity compared with BHT and Trolox. All preparations showed significant effects on wound contraction and the ointment prepared with 10% of essential oil was effective as the reference drug Cicatryl. Conclusions: The essential oil of Artemisia absinthium shows moderate antioxidant activity. The 10% ointment enhances skin wound re-epithelialization and speeds up the healing process. The essential oil of Artemisia absinthium may be used as an alternative drug for wound healing.


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