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  Indian J Med Microbiol
 

Figure 3: Photomicrographs of liver sections from different groups (H & E, ×40). A: the normal control group shows a normal liver architecture including hepatocytes and central vein (CV) with radiating hepatocytes separated by regular sinusoids. B: the CCl4 treated group shows damaged hepatic cells with vacuolated cytoplasm, irregular sinusoids and congested CV along with fibrosis and cellular infiltration. C: the Cystone® group shows the restoration of hepatic architecture. However, binucleated cells can be observed. D: BSVT (25 mg/kg) group shows the least alleviation of toxicity. The congestion due to infiltration of the cell in CV is still prominent along with fibrosis in the proximity of CV. Hydropic degeneration and irregular sinusoids are also visible. E: BSVT (50 mg/ kg) group shows the hepatic lobules in a nearly hexagonal shape with the CV in the center and abnormal size. The bile duct and the hepatic artery are shown clearly in the picture. F: BSVT (100 mg/kg) treated group shows almost complete restoration of hepatic architecture, CV is distinct and in normal shape, but mild fibrosis can be noticed.

Figure 3: Photomicrographs of liver sections from different groups (H & E, ×40). A: the normal control group shows a normal liver architecture including hepatocytes and central vein (CV) with radiating hepatocytes separated by regular sinusoids. B: the CCl<sub>4</sub> treated group shows damaged hepatic cells with vacuolated cytoplasm, irregular sinusoids and congested CV along with fibrosis and cellular infiltration. C: the Cystone<sup>®</sup> group shows the restoration of hepatic architecture. However, binucleated cells can be observed. D: BSVT (25 mg/kg) group shows the least alleviation of toxicity. The congestion due to infiltration of the cell in CV is still prominent along with fibrosis in the proximity of CV. Hydropic degeneration and irregular sinusoids are also visible. E: BSVT (50 mg/ kg) group shows the hepatic lobules in a nearly hexagonal shape with the CV in the center and abnormal size. The bile duct and the hepatic artery are shown clearly in the picture. F: BSVT (100 mg/kg) treated group shows almost complete restoration of hepatic architecture, CV is distinct and in normal shape, but mild fibrosis can be noticed.