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ORIGINAL ARTICLE
Year : 2020  |  Volume : 10  |  Issue : 9  |  Page : 411-416

Allolobophora caliginosa coelomic fluid ameliorates gentamicin-induced hepatorenal toxicity in rats


1 Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia
2 Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt
3 Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia; Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt

Correspondence Address:
Ayman Saber Mohamed
Department of Zoology, Faculty of Science, Cairo University, Cairo
Egypt
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Source of Support: This study was supported by the Deanship of Scientific Research at King Khalid University through Research Group Project under grant number (R.G.P.1-56 -40), Conflict of Interest: None


DOI: 10.4103/2221-1691.290132

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Objective: To explore the efficacy of earthworm’s coelomic fluid against gentamicin-induced hepatic and renal toxicity in rats. Methods: The animals were divided randomly into three groups (n = 6 per group): control, gentamicin, and Allolobophora caliginosa coelomic fluid-treated groups. Toxicity was established after injection of gentamicin daily for 8 days at a dose of 100 mg/kg. Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total proteins, albumin, creatinine, urea, uric acid, malondialdehyde, glutathione, catalase and histopathology of tissues were investigated in the study. Results: Allolobophora caliginosa coelomic fluid significantly decreased urea, creatinine, uric acid, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and malondialdehyde levels while significantly increasing levels of total proteins, albumin, glutathione and catalase. The histopathological investigation showed partial restoration of renal and hepatic architecture. Conclusions: This study shows the potency of Allolobophora caliginosa coelomic fluid in improving the biochemical and histopathological changes induced by gentamicin in the liver and kidney of the rats.


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