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ORIGINAL ARTICLE
Year : 2020  |  Volume : 10  |  Issue : 1  |  Page : 18-22

Raspberry ketone attenuates high-fat diet-induced obesity by improving metabolic homeostasis in rats


1 University of Jeddah, College of Science, Department of Biology, Jeddah, Saudi Arabia
2 University of Jeddah, College of Science, Department of Biochemistry, Jeddah, Saudi Arabia; Department of Biochemistry, Faculty of Vet. Medicine, Zagazig University, Zagazig, Egypt
3 Department of Biochemistry, Faculty of Vet. Medicine, Zagazig University, Zagazig, Egypt; Department of Basic Medical Sciences, College of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia
4 University of Jeddah, College of Science, Department of Biochemistry, Jeddah, Saudi Arabia

Correspondence Address:
Mohamed Afifi
University of Jeddah, College of Science, Department of Biochemistry, Jeddah, Saudi Arabia; Department of Biochemistry, Faculty of Vet. Medicine, Zagazig University, Zagazig, Egypt

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Source of Support: This work was funded by the University of Jeddah, Saudi Arabia, under Grant No (UJ-18-18-DR), Conflict of Interest: None


DOI: 10.4103/2221-1691.273090

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Objective: To investigate the molecular mechanisms of the anti-obese effect of raspberry ketone against high-fat diet fed rats. Methods: Fifty adult male rats were randomly assigned to receive a standard diet, a high fat diet, and the high-fat diet and 0.5%, 1% or 2% raspberry ketone. Body weight, biochemical parameters and gene expression of CCAAT enhancer-binding protein (C/EBP)δ, fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), peroxisome proliferator-activated receptor alpha (PPAR-α), hormone-sensitive lipase (HSL) and hepatic carnitine palmitoyltransferase 1 A (CPT1A) were investigated. Results: Body weight, blood glucose, insulin, total lipids, triacylglycerols, total cholesterol and low-density lipoprotein cholesterol were increased in high-fat diet fed rats. These high fat diet-induced changes were attenuated by treatment with raspberry ketone. High-density lipoprotein cholesterol was decreased in highfat diet fed rats but increased in rats treated with raspberry ketone. Molecular investigations showed induction of gene expression of C/EBP-δ, FAS, ACC, CPT1A and inhibition of gene expression of PPAR-α and HSL in high-fat diet fed rats as compared with control. Raspberry ketone treament reversed these changes except CPT1A. Conclusions: Raspberry ketone can prevent obesity induced by a high-fat diet in rats by induction of the expression of enzymes, controlling lipolysis and fatty acids β oxidation as well as inhibition of gene expressions of adipogenic factors.


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