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ORIGINAL ARTICLE
Year : 2019  |  Volume : 9  |  Issue : 5  |  Page : 188-195

p-Coumaric acid ameliorates ethanol–induced kidney injury by inhibiting inflammatory cytokine production and NF–κB signaling in rats


1 Department of Biomedical Science, Bharathidasan University, Tiruchirappalli, Tamilnadu, India
2 Department of Biochemistry and Biotechnology, Annnamalai University, Annamalainagar-608 002, Tamil Nadu, India

Correspondence Address:
Dr. Mathan Ganeshan
Department of Biomedical Science, Bharathidasan University, Tiruchirappalli, Tamilnadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2221-1691.258998

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Objective: To examine the effects of p-coumaric acid on ethanol-induced kidney injury in Swiss Wistar rats. Methods: Ethanol (25% v/v) was used to induce nephrotoxicity in rats. p-Coumaric acid was orally administered at 50, 100, or 200 mg/kg body weight. The levels of oxidative parameters were determined; pro-inflammatory biomarkers were analyzed by Western blotting and apoptotic protein was analyzed by immunohistochemistry. Results: Ethanol treated rats showed decreased levels of antioxidants and aberrant production of pro-inflammatory cytokines (IL-6, IL1P, TNF-α), NF-κB activation and imbalance of pro- and anti-apoptotic proteins (Bcl-2, Bax, caspase 3). Meanwhile, jp-coumaric acid restored antioxidant levels and decreased the levels of inflammatory cytokines, NF-κB, and pro- apoptotic proteins and increased Bcl-2 expression. Conclusions: jp-Coumaric acid ameliorates ethanol-induced kidney injury by restoring antioxidant production and suppressing cellular apoptosis and inhibiting NF-κB expression. jp-Coumaric acid should be further investigated as a promising candidate for ethanol-induced kidney toxicity.


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