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BASIC RESEARCH
Year : 2018  |  Volume : 8  |  Issue : 7  |  Page : 340-344

Moderating effect of synthesized docosahexaenoic acid-enriched phosphatidylcholine on production of Th1 and Th2 cytokine in lipopolysaccharide-induced inflammation


1 Department of Mircrobiology, Kosin University College of Medicine, Busan, Korea
2 Division of Marine Bioscience, Korea Maritime and Ocean University, Busan, Korea

Correspondence Address:
S Y Lim
Division of Marine Bioscience, Korea Maritime and Ocean University, Busan
Korea
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2221-1691.237076

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Objective: To evaluate effects of docosahexaenoic acid-enriched phosphatidylcholine (DHA-PC) on cytokine production induced by lipopolysaccharide (LPS). Methods: The culture supernatants of splenocytes exposed to DHA-PC along with LPS were harvested to determine the production of Th 1 (IFN- γ and IL-2) and Th2 [IL-4, IL-5, IL-6 and IL-12/IL-23(p40)] cytokines. Cytokines were measured using ELISA. Results: Co-administration of DHA-PC with LPS resulted in significantly lower IL-2 expression compared to that observed with administration of only LPS (P<0.01). Treatment with DHA-PC and LPS significantly increased IL-5 expression (P<0.01). Moreover, co-administration of DHA-PC with LPS significantly decreased IL-6 and IL-12/IL-23(p40) expressions compared to that observed with administration of only LPS (P<0.01). Conclusions: Our results suggest that DHA-PC inhibits pro-inflammatory cytokines [IL-2, IL-6 and IL-12/IL-23(p40)] expression on induction of inflammation.


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