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BASIC RESEARCH
Year : 2018  |  Volume : 8  |  Issue : 6  |  Page : 292-301

Coriandrum sativum grown under organic or chemical fertilizer effectively prevents DNA damage: Preliminary phytochemical screening, flavonoid content, ESI (-) FT-ICR MS, in vitro antioxidant and in vivo (mice bone marrow) antimutagenic activity against cyclophosphamide


1 Programa de Pós-graduação em Biologia Vegetal, Laboratório de Genética Vegetal e Toxicológica - Departamento de Ciências Biológicas - Universidade Federal do Espírito Santo, 29075-910, Vitoria, Espírito Santo, Brazil
2 Instituto Federal de Educaçã o, Ciê ncia e Tecnologia do Espí rito Santo, 29106-010, Vila Velha, ES, Brazil
3 Laborató rio de Quí mica de Produtos Naturais, Departamento de Ciê ncias Farmacê uticas – Universidade Federal do Espí rito Santo, 29040-090, Vitoria, Espirito Santo, Brazil

Correspondence Address:
Jean Carlos Vencioneck Dutra
Programa de Pós-graduação em Biologia Vegetal, Laboratório de Genética Vegetal e Toxicológica - Departamento de Ciências Biológicas - Universidade Federal do Espirito Santo, 29075-910, Vitoria, Espírito Santo
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2221-1691.235324

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Objective: To evaluate the influence of fertilization and phenological stages on secondary metabolites production and chemoprotective effects of Coriandrum sativum (C. sativum) L. Methods: The plants were grown under organic or chemical fertilizer, collected at vegetative and flowering development stages and their hydroalcoholic extracts were analyzed by phytochemicals methods, mass spectrometry, antioxidant and antimutagenic assays. Results: All extracts exhibited metabolites such as coumarins, flavonoids and steroids, and mass spectrometry showed similar molecular peaks among the extracts evaluated, suggesting the presence of palmitic and α -linolenic acids. Vegetative C. sativum extract grown under chemical fertilizer showed better antioxidant activity, according to the DPPH assay. Vegetative C. sativum extracts grown under organic and chemical fertilizer were able to effectively reduce micronucleous frequency in the simultaneous and pre-treatment protocols, especially reaching 55.90% of damage reduction in the pre-treatment protocol. Conclusions: These findings suggest that chemical fertilization promotes an increase in the content of flavonoids in C. sativum and, consequently, leads to better antioxidant and antimutagenic activities, as well as reinforces the potential uses of this culinary plant in health promotion and disease prevention.


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