• Users Online: 440
  • Print this page
  • Email this page
ANTIMALARIAL RESEARCH
Year : 2018  |  Volume : 8  |  Issue : 5  |  Page : 268-272

Antiplasmodial activity of silver nanoparticles: A novel green synthesis approach


1 Department of Chemistry, Sri Venkateswara College, University of Delhi, Delhi 110 021, India
2 National Institute of Malaria Research, ICMR, New Delhi-110077, India
3 Department of Biochemistry, National Institute for Research in Environmental Health, ICMR, Bhopal, India

Correspondence Address:
Sanjay Kumar
Department of Chemistry, Sri Venkateswara College, University of Delhi, Delhi 110 021
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2221-1691.233008

Get Permissions

Objective: To synthesize silver nanoparticles using silver nitrate by a green technique which involves different compositions of aqueous leaf extracts of Azadirachta indica (neem) and Ocimum sanctum (tulsi). Methods: Their shape and size were determined using transmission electron microscopy and UV-visible spectroscopy. Their antiplasmodial activity was studied using the malarial parasite strain (Plasmodium falciparum, 3D7). The parasite strain (3D7) was collected and revived in vitro using Trager and Jensen method in RPMI 1640 medium for 7-8 cycles. Half maximal effective concentration values were calculated by nonlinear regression analysis. Results: Transmission electron microscopy results confirmed the formation of silver nanoparticles with size ranging from 4.74-39.32 nm and their size differs by varying the concentrations from 20% to 100% of neem extract in neem and tulsi extracts. It was observed that samples B and C showed half maximum effective concentration of about 0.3 μ M. Conclusions: It can be easily established that the aqueous leaf extracts of neem and tulsi in combination can be a good source for synthesis of silver nanoparticles with small size possessing appreciable antiplasmodial activity.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed320    
    Printed20    
    Emailed0    
    PDF Downloaded86    
    Comments [Add]    

Recommend this journal