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BASIC RESEARCH
Year : 2018  |  Volume : 8  |  Issue : 3  |  Page : 137-141

Antioxidant and antiglycation properties of two mango (Mangifera indica L.) cultivars from Senegal


1 Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University. PB 5005 Dakar- Fann, Sénégal
2 Université Clermont Auvergne, INRA, UNH, F-63000 Clermont-Ferrand, France
3 Department of Pharmacology and Toxicology, Faculty of Medicine and Health Sciences (USS). PB 4009 Libreville, Gabon
4 Laboratory of Chemistry, Training and Research Unit of Health, Thiès University. PB 967 Thiés, Sénégal

Correspondence Address:
François Senejoux
Université Clermont Auvergne, INRA, UNH, F-63000 Clermont-Ferrand
France
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2221-1691.227994

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Objective: To evaluate the total phenolic contents, antioxidant and antiglycation activities of leaves, barks, roots and kernels from two cultivars of Mangifera indica (Anacardiaceae). Methods: Total phenolic contents were determined by using Folin-Ciocalteu's method. The antioxidant activities were assessed by three different protocols including DPPH, oxygen radical absorbance capacity and iron (II) chelation assays. In addition, in vitro bovine serum albumin/D-ribose assay was chosen to evaluate the antiglycation properties of the extracts. Results: All the investigated extracts were found to contain high level of total phenols as well as potent antioxidant activities. Kernel extracts showed the highest total phenol contents and DPPH radical scavenging activities whereas higher oxygen radical absorbance capacity values were observed for leave, root and bark extracts. Besides, extracts from leaves, roots and barks from both cultivars exhibited potent inhibitory effects against the formation of advanced glycation end products, with IC50 values lower than the standard positive control aminoguanidine. Conclusions: The potent antiglycation and antioxidative activities of these two Mangifera indica cultivars suggest a possible role in targeting aging, diabetic complications and oxidative stress related diseases.


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