• Users Online: 175
  • Print this page
  • Email this page
BASIC RESEARCH
Year : 2018  |  Volume : 8  |  Issue : 2  |  Page : 92-97

Ethnobotanical database based screening and identification of potential plant species with antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium falciparum


1 P. G. Department of Biosciences, Centre of Advanced Studies, Satellite Campus, Sardar Patel Maidan, Bakrol, Vadtal road, Sardar Patel University, P.O. Box 39, Vallabh Vidyanagar, 388120, Gujarat, India
2 Department of Zoology, Biomedical Technology and Human Genetics, School of Sciences, Gujarat University, Ahmedabad-380009, Gujarat, India

Correspondence Address:
R B Subramanian
P. G. Department of Biosciences, Centre of Advanced Studies, Satellite campus, Sardar Patel Maidan, Bakrol, Vadtal road, Sardar Patel University, P.O. Box 39, Vallabh Vidyanagar, 388120, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2221-1691.225619

Get Permissions

Objective: To evaluate the antiplasmodial activity of aqueous-methanolic plant extracts of nine plant species selected, based on ethnobotanical data. Methods: Based on ethnobotanical database, the selected plants were tested for their antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium falciparum. Qualitative tests and high performance thin layer chromatography analysis were carried out to explore the phytocomponents present in the plant extracts. 1,1-diphenyl-2-picrylhydrazyl antioxidant activity was also determined to check the antioxidant activity of the plant extracts. Results: Moringa oleifera (IC50: 3.906 μg/mL), Acalypha indica (IC50: 3.906 μg/mL), Hyptis suaveolens (IC50: 3.906 μg/mL), Mangifera indica (IC50: 4.150 μg/mL) and Averrhoa bilimbi (IC50: 4.881 μg/mL) showed very good antiplasmodial activity. Conclusions: Crude extracts of Mangifera indica and Hyptis suaveolens demonstrated the most efficacious antimalarial activity. A bioassay-guided fractionation of these extracts to identify the lead compound is proved to be useful. The results validate the traditional use of the selected plants as antimalarials.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed476    
    Printed31    
    Emailed0    
    PDF Downloaded127    
    Comments [Add]    

Recommend this journal