• Users Online: 157
  • Print this page
  • Email this page
BASIC RESEARCH
Year : 2018  |  Volume : 8  |  Issue : 1  |  Page : 19-24

Efficiency of combining pomegranate juice with low-doses of cisplatin and taxotere on A549 human lung adenocarcinoma cells


1 Doctoral School of Science and Technology, Research Platform for Environmental Science (PRASE), Lebanese University, Lebanon
2 Doctoral School of Science and Technology, Research Platform for Environmental Science (PRASE), Lebanese University, Lebanon; Université Fédérale de Toulouse Midi-Pyrénées, INP-ENSIACET, Laboratoire de Chimie Agro-industrielle, Toulouse, France
3 Al Mustansiriya University, College of Science, Department of Biology, Iraq
4 American University of Beirut, Beirut, Lebanon

Correspondence Address:
Hijazi Akram
PhD researcher, Science of Agro-resources (EDST-EDSDM), Platforme de Recherche et d’Analyse en Sciences de l’Environnement, Hadath-Liban, Laboratoire de Chimie Agro-Industrielle, France

Sayed Ahmad Bouchra
PhD researcher, Science of Agro-resources (EDST-EDSDM), Platforme de Recherche et d’Analyse en Sciences de l’Environnement, Hadath-Liban, Laboratoire de Chimie Agro-Industrielle, France

Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2221-1691.221130

Get Permissions

Objective: To test the coalescence effect of two chemotherapy drugs at low effective dose (cisplatin and taxotere) combined with pomegranate juice on A549 cancer cells. Methods: Infrared spectroscopy method is a qualitative test that was performed to ensure the existence of the phytochemicals providing the antioxidant activity through the presence of the hydroxyl group (-OH). The viability of A549 cell line and normal MCs was tested using the neutral red uptake, Clonogenic survival, XTT and Cell migration assays. Results: Our results showed that this combination firstly led to a greater decrease in the viability of cells comparing to those treated with chemotherapy drugs alone, and secondly led to a significant reduction in cell migration. Conclusions: These data suggest a synergistic effect between the pomegranate and cisplatin which makes probably this combination a powerful option for treating lung adenocarcinoma and in parallel minimizing the systemic side effects.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed675    
    Printed45    
    Emailed0    
    PDF Downloaded128    
    Comments [Add]    

Recommend this journal