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BASIC RESEARCH
Year : 2018  |  Volume : 8  |  Issue : 11  |  Page : 554-564

Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos


1 Faculty of Bioresources and Food industry; School of Agriculture Science & Biotechnology, Universiti Sultan Zainal Abidin, Besut Campus, 22200 Besut, Terengganu, Malaysia
2 School of Agriculture Science & Biotechnology, Universiti Sultan Zainal Abidin, Besut Campus, 22200 Besut, Terengganu, Malaysia
3 Faculté des Sciences et Sciences de l’ingénieur (UFR SSI), Centre Yves Coppens, Université Européenne de Bretagne, Campus de Tohannic - BP 573, 56 017 Vannes Cedex, France
4 LBCM, Université Européenne de Bretagne, Campus de Tohannic, BP573, 56017 Vannes Cedex, France
5 Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
6 Institute of Marine Biotechnology, University Malaysia Terengganu, Mengabang Telipot, 21030 Kuala Terengganu, Terengganu, Malaysia

Correspondence Address:
Habsah Mohamad
Institute of Marine Biotechnology, University Malaysia Terengganu, Mengabang Telipot, 21030 Kuala Terengganu, Terengganu
Malaysia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2221-1691.245971

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Objective: To investigate phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos. Methods: Fatty acid methyl ester was analyzed by gas chromatography-flame ionization detector. Antioxidant activity was determined using 2,2-diphenyl-picrylhydrazyl radical scavenging assay and total phenolics content by Folin-Ciocalteu procedure. Vero cells viability was evaluated using methyl thiazole tetrazolium and the inactivation of herpes simplex virus type 1 by neutral red uptake assay. p-Hydroxybenzamide isolated by column chromatography was characterized by utilizing nuclear magnetic resonance spectroscopy and electron impact mass spectrometry. Results: The chloroform, ethyl acetate and methanol extracts of Aaptos aaptos produced higher portions of straight-chain saturated fatty acid, while hexane extract mainly consisted of unsaturated fatty acid. The five majors of fatty acid methyl ester were identified as behenic acid, cis-10-heptadecenoic acid and cis-10-pentadecenoic acids, palmitic acid and tricosanoic acid. In addition, among all organic extracts, chloroform extract inactivated herpes simplex virus type 1 while exhibited weak cytotoxic activity against normal Vero cells and also exhibited strong cytotoxic activity on HL-60, MCF-7, K562, CEM-SS and WEHI-3B cells. A phenolic compound, p-hydroxybenzamide was also isolated from the sponge. Conclusions: Aaptos aaptos could be a source to derive the potential antiviral and anticancer agents. However, further studies are needed to determine the mechanism involved in the process.


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